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Dr. Asit K. Chakraborti Research Group

Organic Chemistry


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Catalysis

Transition-metal catalysed and organocatalytic C-H activations; Noble and non-noble metal derived nanocatalysts; Hetero-bimetallic hybrid nanocatalysts; Late functionalisation of bio-active scaffolds to generate new bio-active carbogens.
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Silver nanoparticle-catalysed phenolysis of epoxides under neutral conditions: Scope and limitations of metal nanoparticles and applications towards drug synthesis
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Palladium catalyzed Csp2–H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals
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Protecting group-free concise synthesis of (RS)/(S)-lubeluzole

Green/Sustainable Chemistry

Heterogeneous/solid-supported catalysts-reactions on solid support; Applications of microwave dielectric heating and ultrasound; Innocuous alternate reaction media- water, ionic liquids, and fluorous solvents; Molecular level understanding of the role of water in promoting organic reactions; Non-solvent (organo-catalytic) uses of ionic liquids and delineating the role and origin of catalysis for predictive modeling of catalyst design.
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On Catalysis by Ionic Liquids

Combinatorial Chemistry

Development of methodologies for solid/solution phase synthesis of small molecular libraries; Strategies for new linkers and analytical protocols.

Natural Products and Drug Synthesis

Synthesis of complex carbocyclic/heterocyclic frameworks; Greener synthetic routes to bio-active natural products, cardiovascular drugs, taxanes, epothilones, eleutherobin, lignans and other biologically active molecules; All-water and protecting group-free synthetic strategies.
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"All water chemistry" for a concise total synthesis of the novel class anti-anginal drug (RS), (R), and (S)-ranolazine

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 Page Last Updated / Reviewed on: July 30, 2018
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