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Dr. Asit K. Chakraborti Research Group

Medicinal Chemistry

 Target-based design and syntheses of new chemical entities for various therapeutic areas :
 Tropical communicable and neglected diseases:
     (a) Tuberculosis: inhibitors of FtsZ protein assembly, His G, isocitrate lyase (ICL), and malate synthase (MS)
     (b) Leishmaniasis: trypanothione reductase (TR), ribose-5-phosphate, and HDAC inhibitors.
 Non-communicable diseases:
     (a) Diabetes: PTP1B, GOAT inhibitors;
     (b) Inflammation: selective COX-2, COX-LOX dual inhibitors for rheumatoid arthritis and their implication in other disease control such as cancer and                         CNS disorder; and PDE-IVB inhibitors for asthma  and COPD
     (c) Cancer: antimitotic agents (second and third generation taxoids, epothiolones and eleutherobins), PKC inhibitors
     (d) Cardiovascular: calcium channel blockers, HMG-CoA reductase inhibitors, endothelin receptor antagonists
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 Page Last Updated / Reviewed on: March 27, 2018
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